| 21 de fev.22:00 |  Inter Miami CF× Real Salt Lake | |  Real Salt Lake |
| 24 de fev.16:00 |  Columbus Crew× Atlanta United | |  Atlanta United |
| 24 de fev.18:45 |  Los Angeles FC× Seattle Sounders FC | |  Seattle Sounders FC |
| 24 de fev.21:30 |  Charlotte FC× New York City FC | |  New York City FC |
| 24 de fev.21:30 |  DC United× New England Revolution | |  New England Revolution |
| 24 de fev.21:30 |  Orlando City SC× CF Montréal | |  CF Montréal |
| 24 de fev.21:30 |  Philadelphia Union× Chicago Fire | |  Chicago Fire |
| 24 de fev.22:30 |  FC Dallas× San Jose Earthquakes | |  San Jose Earthquakes |
| 24 de fev.22:30 |  Houston Dynamo× Sporting Kansas City | |  Sporting Kansas City |
| 24 de fev.22:30 |  Austin FC× Minnesota United | |  Minnesota United |
| 24 de fev.22:30 |  St.Louis City× Real Salt Lake | | Real Salt Lake |
| 25 de fev.00:30 |  Portland Timbers× Colorado Rapids | |  Colorado Rapids |
| 25 de fev.16:30 |  FC Cincinnati× Toronto FC | |  Toronto FC |
| 25 de fev.19:00 |  Nashville SC× New York Red Bulls | |  New York Red Bulls |
| 25 de fev.23:00 |  LA Galaxy× Inter Miami CF | | Inter Miami CF |
| 02 de mar.16:00 | Minnesota United× Columbus Crew | | Columbus Crew |
| 02 de mar.18:00 | Real Salt Lake× Los Angeles FC | | Los Angeles FC |
| 02 de mar.18:30 | Inter Miami CF× Orlando City SC | | Orlando City SC |
| 02 de mar.21:30 |  Vancouver Whitecaps× Charlotte FC | | Charlotte FC |
| 02 de mar.22:30 | Sporting Kansas City× Philadelphia Union | | Philadelphia Union |
| 02 de mar.22:30 | St.Louis City× New York City FC | | New York City FC |
| 02 de mar.22:30 | FC Dallas× CF Montréal | | CF Montréal |
| 02 de mar.22:30 | Houston Dynamo× New York Red Bulls | | New York Red Bulls |
| 02 de mar.22:30 | Chicago Fire× FC Cincinnati | | FC Cincinnati |
| 02 de mar.23:30 | Colorado Rapids× Nashville SC | | Nashville SC |
| 03 de mar.00:30 | San Jose Earthquakes× LA Galaxy | | LA Galaxy |
| 03 de mar.00:30 | Portland Timbers× DC United | | DC United |
| 03 de mar.00:30 | Seattle Sounders FC× Austin FC | | Austin FC |
| 03 de mar.16:00 | New England Revolution× Toronto FC | | Toronto FC |
| 09 de mar.16:00 | New York City FC× Portland Timbers | | Portland Timbers |
| 09 de mar.16:00 | Toronto FC× Charlotte FC | | Charlotte FC |
| 09 de mar.21:30 | Orlando City SC× Minnesota United | | Minnesota United |
| 09 de mar.21:30 | Columbus Crew× Chicago Fire | | Chicago Fire |
| 09 de mar.21:30 | New York Red Bulls× FC Dallas | | FC Dallas |
| 09 de mar.21:30 | Atlanta United× New England Revolution | | New England Revolution |
| 09 de mar.22:30 | Austin FC× St.Louis City | | St.Louis City |
| 09 de mar.23:30 | Real Salt Lake× Colorado Rapids | | Colorado Rapids |
| 10 de mar.00:30 | Los Angeles FC× Sporting Kansas City | | Sporting Kansas City |
| 10 de mar.00:30 | San Jose Earthquakes× Vancouver Whitecaps | | Vancouver Whitecaps |
| 10 de mar.16:00 | FC Cincinnati× DC United | | DC United |
| 10 de mar.16:00 | Nashville SC× LA Galaxy | | LA Galaxy |
| 10 de mar.18:00 | Inter Miami CF× CF Montréal | | CF Montréal |
| 16 de mar.15:00 | DC United× Inter Miami CF | | Inter Miami CF |
| 16 de mar.15:00 | Chicago Fire× CF Montréal | | CF Montréal |
| 16 de mar.16:30 | Seattle Sounders FC× Colorado Rapids | | Colorado Rapids |
| 16 de mar.20:30 | Columbus Crew× New York Red Bulls | | New York Red Bulls |
| 16 de mar.20:30 | New York City FC× Toronto FC | | Toronto FC |
| 16 de mar.21:30 | Minnesota United× Los Angeles FC | | Los Angeles FC |
| 16 de mar.21:30 | Austin FC× Philadelphia Union | | Philadelphia Union |
| 16 de mar.21:30 | Nashville SC× Charlotte FC | | Charlotte FC |
| 16 de mar.21:30 | FC Dallas× Vancouver Whitecaps | | Vancouver Whitecaps |
| 16 de mar.21:30 | Sporting Kansas City× San Jose Earthquakes | | San Jose Earthquakes |
| 16 de mar.21:30 | Houston Dynamo× Portland Timbers | | Portland Timbers |
| 16 de mar.23:30 | LA Galaxy× St.Louis City | | St.Louis City |
| 17 de mar.15:00 | New England Revolution× FC Cincinnati | | FC Cincinnati |
| 17 de mar.20:00 | Atlanta United× Orlando City SC | | Orlando City SC |
| 23 de mar.15:00 | New England Revolution× Chicago Fire | | Chicago Fire |
| 23 de mar.15:00 | New York Red Bulls× Inter Miami CF | | Inter Miami CF |
| 23 de mar.20:30 | FC Cincinnati× New York City FC | | New York City FC |
| 23 de mar.20:30 | Toronto FC× Atlanta United | | Atlanta United |
| 23 de mar.20:30 | Orlando City SC× Austin FC | | Austin FC |
| 23 de mar.20:30 | Vancouver Whitecaps× Real Salt Lake | | Real Salt Lake |
| 23 de mar.20:30 | Charlotte FC× Columbus Crew | | Columbus Crew |
| 23 de mar.21:30 | Sporting Kansas City× LA Galaxy | | LA Galaxy |
| 23 de mar.21:30 | St.Louis City× DC United | | DC United |
| 23 de mar.22:30 | Colorado Rapids× Houston Dynamo | | Houston Dynamo |
| 23 de mar.23:30 | Portland Timbers× Philadelphia Union | | Philadelphia Union |
| 23 de mar.23:30 | San Jose Earthquakes× Seattle Sounders FC | | Seattle Sounders FC |
| 23 de mar.23:30 | Los Angeles FC× Nashville SC | | Nashville SC |
| 30 de mar.15:00 | Philadelphia Union× Minnesota United | | Minnesota United |
| 30 de mar.17:00 | Colorado Rapids× Los Angeles FC | | Los Angeles FC |
| 30 de mar.20:30 | Inter Miami CF× New York City FC | | New York City FC |
| 30 de mar.20:30 | Orlando City SC× New York Red Bulls | | New York Red Bulls |
| 30 de mar.20:30 | Toronto FC× Sporting Kansas City | | Sporting Kansas City |
| 30 de mar.20:30 | DC United× CF Montréal | | CF Montréal |
| 30 de mar.20:30 | Charlotte FC× FC Cincinnati | | FC Cincinnati |
| 30 de mar.21:30 | Austin FC× FC Dallas | | FC Dallas |
| 30 de mar.21:30 | Houston Dynamo× San Jose Earthquakes | | San Jose Earthquakes |
| 30 de mar.21:30 | Nashville SC× Columbus Crew | | Columbus Crew |
| 30 de mar.22:30 | Real Salt Lake× St.Louis City | | St.Louis City |
| 30 de mar.23:30 | LA Galaxy× Seattle Sounders FC | | Seattle Sounders FC |
| 30 de mar.23:30 | Vancouver Whitecaps× Portland Timbers | | Portland Timbers |
| 31 de mar.16:30 | Atlanta United× Chicago Fire | | Chicago Fire |
| 06 de abr.20:30 | Inter Miami CF× Colorado Rapids | | Colorado Rapids |
| 06 de abr.20:30 | FC Cincinnati× New York Red Bulls | | New York Red Bulls |
| 06 de abr.20:30 | New York City FC× Atlanta United | | Atlanta United |
| 06 de abr.20:30 | Vancouver Whitecaps× Toronto FC | | Toronto FC |
| 06 de abr.20:30 | Columbus Crew× DC United | | DC United |
| 06 de abr.20:30 | New England Revolution× Charlotte FC | | Charlotte FC |
| 06 de abr.20:45 | Los Angeles FC× LA Galaxy | | LA Galaxy |
| 06 de abr.21:30 | Nashville SC× Philadelphia Union | | Philadelphia Union |
| 06 de abr.21:30 | Chicago Fire× Houston Dynamo | | Houston Dynamo |
| 06 de abr.21:30 | Minnesota United× Real Salt Lake | | Real Salt Lake |
| 06 de abr.21:30 | Austin FC× San Jose Earthquakes | | San Jose Earthquakes |
| 06 de abr.21:30 | St.Louis City× FC Dallas | | FC Dallas |
| 06 de abr.23:30 | Seattle Sounders FC× CF Montréal | | CF Montréal |
| 07 de abr.14:45 | Sporting Kansas City× Portland Timbers | | Portland Timbers |
| 13 de abr.17:45 | Portland Timbers× Los Angeles FC | | Los Angeles FC |
| 13 de abr.20:30 | CF Montréal× FC Cincinnati | | FC Cincinnati |
| 13 de abr.20:30 | New York City FC× New England Revolution | | New England Revolution |
| 13 de abr.20:30 | DC United× Orlando City SC | | Orlando City SC |
| 13 de abr.20:30 | Charlotte FC× Toronto FC | | Toronto FC |
| 13 de abr.20:30 | New York Red Bulls× Chicago Fire | | Chicago Fire |
| 13 de abr.21:30 | Minnesota United× Houston Dynamo | | Houston Dynamo |
| 13 de abr.21:30 | Sporting Kansas City× Inter Miami CF | | Inter Miami CF |
| 13 de abr.21:30 | FC Dallas× Seattle Sounders FC | | Seattle Sounders FC |
| 13 de abr.22:30 | Real Salt Lake× Columbus Crew | | Columbus Crew |
| 13 de abr.23:30 | Vancouver Whitecaps× LA Galaxy | | LA Galaxy |
| 13 de abr.23:30 | San Jose Earthquakes× Colorado Rapids | | Colorado Rapids |
| 14 de abr.15:30 | Atlanta United× Philadelphia Union | | Philadelphia Union |
| 14 de abr.17:45 | St.Louis City× Austin FC | | Austin FC |
| 20 de abr.20:30 | Inter Miami CF× Nashville SC | | Nashville SC |
| 20 de abr.20:30 | Atlanta United× FC Cincinnati | | FC Cincinnati |
| 20 de abr.20:30 | CF Montréal× Orlando City SC | | Orlando City SC |
| 20 de abr.20:30 | Toronto FC× New England Revolution | | New England Revolution |
| 20 de abr.20:30 | Columbus Crew× Portland Timbers | | Portland Timbers |
| 20 de abr.20:30 | New York City FC× DC United | | DC United |
| 20 de abr.21:30 | Houston Dynamo× Austin FC | | Austin FC |
| 20 de abr.21:30 | Sporting Kansas City× St.Louis City | | St.Louis City |
| 20 de abr.21:30 | Chicago Fire× Real Salt Lake | | Real Salt Lake |
| 20 de abr.22:30 | Colorado Rapids× FC Dallas | | FC Dallas |
| 20 de abr.23:30 | Los Angeles FC× New York Red Bulls | | New York Red Bulls |
| 20 de abr.23:30 | Seattle Sounders FC× Vancouver Whitecaps | | Vancouver Whitecaps |
| 21 de abr.19:00 | Charlotte FC× Minnesota United | | Minnesota United |
| 21 de abr.21:15 | LA Galaxy× San Jose Earthquakes | | San Jose Earthquakes |
| 27 de abr.14:45 | Austin FC× LA Galaxy | | LA Galaxy |
| 27 de abr.20:30 | New York Red Bulls× Vancouver Whitecaps | | Vancouver Whitecaps |
| 27 de abr.20:30 | DC United× Seattle Sounders FC | | Seattle Sounders FC |
| 27 de abr.20:30 | New England Revolution× Inter Miami CF | | Inter Miami CF |
| 27 de abr.20:30 | Orlando City SC× Toronto FC | | Toronto FC |
| 27 de abr.20:30 | FC Cincinnati× Colorado Rapids | | Colorado Rapids |
| 27 de abr.20:30 | New York City FC× Charlotte FC | | Charlotte FC |
| 27 de abr.20:30 | Philadelphia Union× Real Salt Lake | | Real Salt Lake |
| 27 de abr.20:30 | Columbus Crew× CF Montréal | | CF Montréal |
| 27 de abr.21:30 | Nashville SC× San Jose Earthquakes | | San Jose Earthquakes |
| 27 de abr.21:30 | Chicago Fire× Atlanta United | | Atlanta United |
| 27 de abr.21:30 | Minnesota United× Sporting Kansas City | | Sporting Kansas City |
| 27 de abr.21:30 | FC Dallas× Houston Dynamo | | Houston Dynamo |
| 27 de abr.23:30 | Los Angeles FC× Portland Timbers | | Portland Timbers |
| 30 de abr.20:30 | Philadelphia Union× Seattle Sounders FC | | Seattle Sounders FC |
| 04 de mai.20:30 | Toronto FC× FC Dallas | | FC Dallas |
| 04 de mai.20:30 | Atlanta United× Minnesota United | | Minnesota United |
| 04 de mai.20:30 | DC United× Philadelphia Union | | Philadelphia Union |
| 04 de mai.20:30 | Orlando City SC× FC Cincinnati | | FC Cincinnati |
| 04 de mai.20:30 | San Jose Earthquakes× Los Angeles FC | | Los Angeles FC |
| 04 de mai.20:30 | Inter Miami CF× New York Red Bulls | | New York Red Bulls |
| 04 de mai.20:30 | Charlotte FC× Portland Timbers | | Portland Timbers |
| 04 de mai.21:30 | Houston Dynamo× St.Louis City | | St.Louis City |
| 04 de mai.21:30 | Nashville SC× CF Montréal | | CF Montréal |
| 04 de mai.22:25 | Chicago Fire× New England Revolution | | New England Revolution |
| 04 de mai.22:30 | Real Salt Lake× Sporting Kansas City | | Sporting Kansas City |
| 04 de mai.23:30 | Vancouver Whitecaps× Austin FC | | Austin FC |
| 05 de mai.17:00 | New York City FC× Colorado Rapids | | Colorado Rapids |
| 05 de mai.19:45 | Seattle Sounders FC× LA Galaxy | | LA Galaxy |
| 11 de mai.20:30 | CF Montréal× Inter Miami CF | | Inter Miami CF |
| 11 de mai.20:30 | Philadelphia Union× Orlando City SC | | Orlando City SC |
| 11 de mai.20:30 | Toronto FC× New York City FC | | New York City FC |
| 11 de mai.20:30 | Atlanta United× DC United | | DC United |
| 11 de mai.20:30 | Charlotte FC× Nashville SC | | Nashville SC |
| 11 de mai.20:30 | New York Red Bulls× New England Revolution | | New England Revolution |
| 11 de mai.20:45 | Columbus Crew× FC Cincinnati | | FC Cincinnati |
| 11 de mai.21:30 | FC Dallas× Austin FC | | Austin FC |
| 11 de mai.21:30 | St.Louis City× Chicago Fire | | Chicago Fire |
| 11 de mai.21:30 | Sporting Kansas City× Houston Dynamo | | Houston Dynamo |
| 11 de mai.22:30 | Colorado Rapids× San Jose Earthquakes | | San Jose Earthquakes |
| 11 de mai.23:30 | LA Galaxy× Real Salt Lake | | Real Salt Lake |
| 11 de mai.23:30 | Los Angeles FC× Vancouver Whitecaps | | Vancouver Whitecaps |
| 12 de mai.17:45 | Portland Timbers× Seattle Sounders FC | | Seattle Sounders FC |
| 15 de mai.20:30 | CF Montréal× Columbus Crew | | Columbus Crew |
| 15 de mai.20:30 | DC United× New York Red Bulls | | New York Red Bulls |
| 15 de mai.20:30 | Philadelphia Union× New York City FC | | New York City FC |
| 15 de mai.20:30 | Orlando City SC× Inter Miami CF | | Inter Miami CF |
| 15 de mai.20:30 | FC Cincinnati× Atlanta United | | Atlanta United |
| 15 de mai.21:30 | Chicago Fire× Charlotte FC | | Charlotte FC |
| 15 de mai.21:30 | Austin FC× Houston Dynamo | | Houston Dynamo |
| 15 de mai.21:30 | Minnesota United× LA Galaxy | | LA Galaxy |
| 15 de mai.21:30 | St.Louis City× Los Angeles FC | | Los Angeles FC |
| 15 de mai.21:30 | Nashville SC× Toronto FC | | Toronto FC |
| 15 de mai.22:30 | Colorado Rapids× Vancouver Whitecaps | | Vancouver Whitecaps |
| 15 de mai.22:30 | Real Salt Lake× Seattle Sounders FC | | Seattle Sounders FC |
| 15 de mai.23:30 | Portland Timbers× San Jose Earthquakes | | San Jose Earthquakes |
| 18 de mai.14:45 | Nashville SC× Atlanta United | | Atlanta United |
| 18 de mai.20:30 | Toronto FC× CF Montréal | | CF Montréal |
| 18 de mai.20:30 | FC Cincinnati× St.Louis City | | St.Louis City |
| 18 de mai.20:30 | New England Revolution× Philadelphia Union | | Philadelphia Union |
| 18 de mai.20:30 | Charlotte FC× LA Galaxy | | LA Galaxy |
| 18 de mai.20:30 | New York City FC× New York Red Bulls | | New York Red Bulls |
| 18 de mai.21:05 | Inter Miami CF× DC United | | DC United |
| 18 de mai.21:30 | Houston Dynamo× FC Dallas | | FC Dallas |
| 18 de mai.21:30 | Austin FC× Sporting Kansas City | | Sporting Kansas City |
| 18 de mai.21:30 | Minnesota United× Portland Timbers | | Portland Timbers |
| 18 de mai.21:30 | Chicago Fire× Columbus Crew | | Columbus Crew |
| 18 de mai.22:30 | Real Salt Lake× Colorado Rapids | | Colorado Rapids |
| 18 de mai.23:30 | Seattle Sounders FC× Vancouver Whitecaps | | Vancouver Whitecaps |
| 18 de mai.23:30 | San Jose Earthquakes× Orlando City SC | | Orlando City SC |
| 25 de mai.20:30 | DC United× Chicago Fire | | Chicago Fire |
| 25 de mai.20:30 | Charlotte FC× Philadelphia Union | | Philadelphia Union |
| 25 de mai.20:30 | New England Revolution× New York City FC | | New York City FC |
| 25 de mai.20:30 | Orlando City SC× Columbus Crew | | Columbus Crew |
| 25 de mai.20:30 | Toronto FC× FC Cincinnati | | FC Cincinnati |
| 25 de mai.20:30 | Atlanta United× Los Angeles FC | | Los Angeles FC |
| 25 de mai.20:30 | CF Montréal× Nashville SC | | Nashville SC |
| 25 de mai.21:30 | FC Dallas× Real Salt Lake | | Real Salt Lake |
| 25 de mai.21:30 | St.Louis City× Seattle Sounders FC | | Seattle Sounders FC |
| 25 de mai.22:30 | Colorado Rapids× Minnesota United | | Minnesota United |
| 25 de mai.23:30 | San Jose Earthquakes× Austin FC | | Austin FC |
| 25 de mai.23:30 | Portland Timbers× Sporting Kansas City | | Sporting Kansas City |
| 25 de mai.23:30 | Vancouver Whitecaps× Inter Miami CF | | Inter Miami CF |
| 25 de mai.23:30 | LA Galaxy× Houston Dynamo | | Houston Dynamo |
| 29 de mai.20:30 | CF Montréal× DC United | | DC United |
| 29 de mai.20:30 | Philadelphia Union× Toronto FC | | Toronto FC |
| 29 de mai.20:30 | FC Cincinnati× Nashville SC | | Nashville SC |
| 29 de mai.20:30 | Inter Miami CF× Atlanta United | | Atlanta United |
| 29 de mai.20:30 | New York Red Bulls× Charlotte FC | | Charlotte FC |
| 29 de mai.21:30 | Houston Dynamo× Colorado Rapids | | Colorado Rapids |
| 29 de mai.21:30 | Sporting Kansas City× Vancouver Whitecaps | | Vancouver Whitecaps |
| 29 de mai.21:30 | Austin FC× Portland Timbers | | Portland Timbers |
| 29 de mai.21:30 | Chicago Fire× Orlando City SC | | Orlando City SC |
| 29 de mai.23:30 | Seattle Sounders FC× Real Salt Lake | | Real Salt Lake |
| 29 de mai.23:30 | LA Galaxy× FC Dallas | | FC Dallas |
| 29 de mai.23:45 | Los Angeles FC× Minnesota United | | Minnesota United |
| 31 de mai.20:30 | New York City FC× San Jose Earthquakes | | San Jose Earthquakes |
| 01 de jun.20:30 | Inter Miami CF× St.Louis City | | St.Louis City |
| 01 de jun.20:30 | DC United× Toronto FC | | Toronto FC |
| 01 de jun.20:30 | Philadelphia Union× CF Montréal | | CF Montréal |
| 01 de jun.20:30 | New York Red Bulls× Orlando City SC | | Orlando City SC |
| 01 de jun.21:30 | Minnesota United× Sporting Kansas City | | Sporting Kansas City |
| 01 de jun.21:30 | Nashville SC× New England Revolution | | New England Revolution |
| 01 de jun.21:30 | Chicago Fire× LA Galaxy | | LA Galaxy |
| 01 de jun.22:30 | Real Salt Lake× Austin FC | | Austin FC |
| 01 de jun.23:30 | Vancouver Whitecaps× Colorado Rapids | | Colorado Rapids |
| 01 de jun.23:30 | Portland Timbers× Houston Dynamo | | Houston Dynamo |
| 01 de jun.23:30 | Los Angeles FC× FC Dallas | | FC Dallas |
| 02 de jun.17:45 | Atlanta United× Charlotte FC | | Charlotte FC |
| 08 de jun.20:30 | New England Revolution× New York Red Bulls | | New York Red Bulls |
| 08 de jun.21:30 | Sporting Kansas City× Seattle Sounders FC | | Seattle Sounders FC |
| 08 de jun.21:30 | St.Louis City× Portland Timbers | | Portland Timbers |
| 08 de jun.21:30 | Minnesota United× FC Dallas | | FC Dallas |
| 14 de jun.21:40 | New York City FC× Columbus Crew | | Columbus Crew |
| 15 de jun.20:30 | Charlotte FC× DC United | | DC United |
| 15 de jun.20:30 | New England Revolution× Vancouver Whitecaps | | Vancouver Whitecaps |
| 15 de jun.20:30 | Toronto FC× Chicago Fire | | Chicago Fire |
| 15 de jun.20:30 | Atlanta United× Houston Dynamo | | Houston Dynamo |
| 15 de jun.20:30 | New York Red Bulls× Nashville SC | | Nashville SC |
| 15 de jun.20:30 | Orlando City SC× Los Angeles FC | | Los Angeles FC |
| 15 de jun.20:30 | CF Montréal× Real Salt Lake | | Real Salt Lake |
| 15 de jun.20:30 | Philadelphia Union× Inter Miami CF | | Inter Miami CF |
| 15 de jun.21:30 | FC Dallas× St.Louis City | | St.Louis City |
| 15 de jun.22:30 | Colorado Rapids× Austin FC | | Austin FC |
| 15 de jun.23:30 | Seattle Sounders FC× Minnesota United | | Minnesota United |
| 15 de jun.23:30 | San Jose Earthquakes× FC Cincinnati | | FC Cincinnati |
| 15 de jun.23:30 | LA Galaxy× Sporting Kansas City | | Sporting Kansas City |
| 19 de jun.20:30 | Toronto FC× Nashville SC | | Nashville SC |
| 19 de jun.20:30 | CF Montréal× New York Red Bulls | | New York Red Bulls |
| 19 de jun.20:30 | Inter Miami CF× Columbus Crew | | Columbus Crew |
| 19 de jun.20:30 | Charlotte FC× Orlando City SC | | Orlando City SC |
| 19 de jun.20:30 | DC United× Atlanta United | | Atlanta United |
| 19 de jun.20:45 | FC Cincinnati× Philadelphia Union | | Philadelphia Union |
| 19 de jun.21:30 | FC Dallas× Minnesota United | | Minnesota United |
| 19 de jun.21:30 | Houston Dynamo× Seattle Sounders FC | | Seattle Sounders FC |
| 19 de jun.21:30 | Sporting Kansas City× Real Salt Lake | | Real Salt Lake |
| 19 de jun.21:30 | Austin FC× Los Angeles FC | | Los Angeles FC |
| 19 de jun.21:30 | St.Louis City× Colorado Rapids | | Colorado Rapids |
| 19 de jun.23:30 | LA Galaxy× New York City FC | | New York City FC |
| 19 de jun.23:30 | San Jose Earthquakes× Portland Timbers | | Portland Timbers |
| 22 de jun.20:30 | Orlando City SC× Chicago Fire | | Chicago Fire |
| 22 de jun.20:30 | DC United× Houston Dynamo | | Houston Dynamo |
| 22 de jun.20:30 | FC Cincinnati× New England Revolution | | New England Revolution |
| 22 de jun.20:30 | Columbus Crew× Sporting Kansas City | | Sporting Kansas City |
| 22 de jun.20:30 | Philadelphia Union× Charlotte FC | | Charlotte FC |
| 22 de jun.20:30 | New York Red Bulls× Toronto FC | | Toronto FC |
| 22 de jun.21:30 | St.Louis City× Atlanta United | | Atlanta United |
| 22 de jun.21:30 | Minnesota United× Austin FC | | Austin FC |
| 22 de jun.21:30 | Nashville SC× New York City FC | | New York City FC |
| 22 de jun.22:30 | Real Salt Lake× LA Galaxy | | LA Galaxy |
| 22 de jun.22:30 | Colorado Rapids× CF Montréal | | CF Montréal |
| 22 de jun.23:30 | Portland Timbers× Vancouver Whitecaps | | Vancouver Whitecaps |
| 22 de jun.23:30 | Seattle Sounders FC× FC Dallas | | FC Dallas |
| 22 de jun.23:30 | Los Angeles FC× San Jose Earthquakes | | San Jose Earthquakes |
| 28 de jun.20:30 | New York City FC× Orlando City SC | | Orlando City SC |
| 29 de jun.20:30 | New England Revolution× Columbus Crew | | Columbus Crew |
| 29 de jun.20:30 | New York Red Bulls× DC United | | DC United |
| 29 de jun.20:30 | CF Montréal× Philadelphia Union | | Philadelphia Union |
| 29 de jun.20:30 | Atlanta United× Toronto FC | | Toronto FC |
| 29 de jun.21:30 | Sporting Kansas City× Austin FC | | Austin FC |
| 29 de jun.21:30 | Houston Dynamo× Charlotte FC | | Charlotte FC |
| 29 de jun.21:30 | FC Dallas× FC Cincinnati | | FC Cincinnati |
| 29 de jun.21:30 | Nashville SC× Inter Miami CF | | Inter Miami CF |
| 29 de jun.23:30 | Vancouver Whitecaps× St.Louis City | | St.Louis City |
| 29 de jun.23:30 | Portland Timbers× Minnesota United | | Minnesota United |
| 29 de jun.23:30 | Seattle Sounders FC× Chicago Fire | | Chicago Fire |
| 29 de jun.23:30 | San Jose Earthquakes× LA Galaxy | | LA Galaxy |
| 29 de jun.23:30 | Los Angeles FC× Colorado Rapids | | Colorado Rapids |
| 03 de jul.20:30 | Toronto FC× Orlando City SC | | Orlando City SC |
| 03 de jul.20:30 | DC United× FC Cincinnati | | FC Cincinnati |
| 03 de jul.20:30 | Charlotte FC× Inter Miami CF | | Inter Miami CF |
| 03 de jul.20:30 | New York City FC× CF Montréal | | CF Montréal |
| 03 de jul.20:45 | New England Revolution× Atlanta United | | Atlanta United |
| 03 de jul.21:30 | Minnesota United× Vancouver Whitecaps | | Vancouver Whitecaps |
| 03 de jul.21:30 | St.Louis City× San Jose Earthquakes | | San Jose Earthquakes |
| 03 de jul.21:30 | Chicago Fire× Philadelphia Union | | Philadelphia Union |
| 03 de jul.21:45 | Columbus Crew× Nashville SC | | Nashville SC |
| 03 de jul.22:30 | Real Salt Lake× Houston Dynamo | | Houston Dynamo |
| 04 de jul.21:30 | FC Dallas× Portland Timbers | | Portland Timbers |
| 04 de jul.22:30 | Colorado Rapids× Sporting Kansas City | | Sporting Kansas City |
| 04 de jul.23:40 | LA Galaxy× Los Angeles FC | | Los Angeles FC |
| 06 de jul.20:30 | CF Montréal× Vancouver Whitecaps | | Vancouver Whitecaps |
| 06 de jul.20:30 | Columbus Crew× Toronto FC | | Toronto FC |
| 06 de jul.20:30 | Philadelphia Union× New York Red Bulls | | New York Red Bulls |
| 06 de jul.20:30 | FC Cincinnati× Inter Miami CF | | Inter Miami CF |
| 06 de jul.20:30 | Orlando City SC× DC United | | DC United |
| 06 de jul.21:30 | Austin FC× New York City FC | | New York City FC |
| 06 de jul.22:30 | Real Salt Lake× Atlanta United | | Atlanta United |
| 06 de jul.23:30 | Seattle Sounders FC× New England Revolution | | New England Revolution |
| 07 de jul.21:30 | Sporting Kansas City× FC Dallas | | FC Dallas |
| 07 de jul.21:30 | San Jose Earthquakes× Chicago Fire | | Chicago Fire |
| 07 de jul.22:30 | Colorado Rapids× St.Louis City | | St.Louis City |
| 07 de jul.23:30 | Portland Timbers× Nashville SC | | Nashville SC |
| 07 de jul.23:30 | LA Galaxy× Minnesota United | | Minnesota United |
| 13 de jul.20:30 | CF Montréal× Atlanta United | | Atlanta United |
| 13 de jul.20:30 | Toronto FC× Philadelphia Union | | Philadelphia Union |
| 13 de jul.20:30 | New England Revolution× Orlando City SC | | Orlando City SC |
| 13 de jul.20:30 | FC Cincinnati× Charlotte FC | | Charlotte FC |
| 13 de jul.20:30 | DC United× Nashville SC | | Nashville SC |
| 13 de jul.21:30 | Houston Dynamo× Minnesota United | | Minnesota United |
| 13 de jul.21:30 | FC Dallas× LA Galaxy | | LA Galaxy |
| 13 de jul.21:30 | Austin FC× Seattle Sounders FC | | Seattle Sounders FC |
| 13 de jul.21:30 | Chicago Fire× New York City FC | | New York City FC |
| 13 de jul.21:30 | St.Louis City× Vancouver Whitecaps | | Vancouver Whitecaps |
| 13 de jul.22:30 | Colorado Rapids× New York Red Bulls | | New York Red Bulls |
| 13 de jul.23:25 | Portland Timbers× Real Salt Lake | | Real Salt Lake |
| 13 de jul.23:30 | San Jose Earthquakes× Sporting Kansas City | | Sporting Kansas City |
| 13 de jul.23:30 | Los Angeles FC× Columbus Crew | | Columbus Crew |
| 17 de jul.20:30 | Columbus Crew× Charlotte FC | | Charlotte FC |
| 17 de jul.20:30 | New York Red Bulls× CF Montréal | | CF Montréal |
| 17 de jul.20:30 | FC Cincinnati× Chicago Fire | | Chicago Fire |
| 17 de jul.20:30 | Atlanta United× New York City FC | | New York City FC |
| 17 de jul.20:30 | Inter Miami CF× Toronto FC | | Toronto FC |
| 17 de jul.20:30 | Philadelphia Union× New England Revolution | | New England Revolution |
| 17 de jul.21:30 | Minnesota United× DC United | | DC United |
| 17 de jul.21:30 | FC Dallas× Austin FC | | Austin FC |
| 17 de jul.21:30 | Nashville SC× Orlando City SC | | Orlando City SC |
| 17 de jul.23:30 | Seattle Sounders FC× St.Louis City | | St.Louis City |
| 17 de jul.23:30 | LA Galaxy× Colorado Rapids | | Colorado Rapids |
| 17 de jul.23:30 | Vancouver Whitecaps× Sporting Kansas City | | Sporting Kansas City |
| 17 de jul.23:30 | San Jose Earthquakes× Houston Dynamo | | Houston Dynamo |
| 17 de jul.23:45 | Los Angeles FC× Real Salt Lake | | Real Salt Lake |
| 20 de jul.20:30 | New England Revolution× FC Dallas | | FC Dallas |
| 20 de jul.20:30 | Philadelphia Union× Nashville SC | | Nashville SC |
| 20 de jul.20:30 | Atlanta United× Columbus Crew | | Columbus Crew |
| 20 de jul.20:30 | Orlando City SC× New York City FC | | New York City FC |
| 20 de jul.20:30 | New York Red Bulls× FC Cincinnati | | FC Cincinnati |
| 20 de jul.20:30 | CF Montréal× Toronto FC | | Toronto FC |
| 20 de jul.20:30 | Inter Miami CF× Chicago Fire | | Chicago Fire |
| 20 de jul.21:30 | Minnesota United× San Jose Earthquakes | | San Jose Earthquakes |
| 20 de jul.21:30 | Austin FC× Charlotte FC | | Charlotte FC |
| 20 de jul.21:30 | Sporting Kansas City× St.Louis City | | St.Louis City |
| 20 de jul.22:30 | Colorado Rapids× Real Salt Lake | | Real Salt Lake |
| 20 de jul.23:30 | Vancouver Whitecaps× Houston Dynamo | | Houston Dynamo |
| 20 de jul.23:30 | Seattle Sounders FC× Los Angeles FC | | Los Angeles FC |
| 20 de jul.23:45 | LA Galaxy× Portland Timbers | | Portland Timbers |
| 24 de ago.19:45 | Minnesota United× Seattle Sounders FC | | Seattle Sounders FC |
| 24 de ago.20:30 | DC United× FC Dallas | | FC Dallas |
| 24 de ago.20:30 | CF Montréal× New England Revolution | | New England Revolution |
| 24 de ago.20:30 | Charlotte FC× New York Red Bulls | | New York Red Bulls |
| 24 de ago.20:30 | New York City FC× Chicago Fire | | Chicago Fire |
| 24 de ago.20:30 | Inter Miami CF× FC Cincinnati | | FC Cincinnati |
| 24 de ago.21:30 | Sporting Kansas City× Orlando City SC | | Orlando City SC |
| 24 de ago.21:30 | Nashville SC× Austin FC | | Austin FC |
| 24 de ago.21:30 | Houston Dynamo× Toronto FC | | Toronto FC |
| 24 de ago.22:30 | Real Salt Lake× San Jose Earthquakes | | San Jose Earthquakes |
| 24 de ago.23:30 | LA Galaxy× Atlanta United | | Atlanta United |
| 24 de ago.23:30 | Portland Timbers× St.Louis City | | St.Louis City |
| 28 de ago.20:30 | Philadelphia Union× Columbus Crew | | Columbus Crew |
| 31 de ago.20:30 | Charlotte FC× Atlanta United | | Atlanta United |
| 31 de ago.20:30 | Orlando City SC× Nashville SC | | Nashville SC |
| 31 de ago.20:30 | New York Red Bulls× Philadelphia Union | | Philadelphia Union |
| 31 de ago.20:30 | Columbus Crew× New York City FC | | New York City FC |
| 31 de ago.20:30 | Toronto FC× DC United | | DC United |
| 31 de ago.20:30 | FC Cincinnati× CF Montréal | | CF Montréal |
| 31 de ago.21:30 | FC Dallas× Colorado Rapids | | Colorado Rapids |
| 31 de ago.21:30 | Chicago Fire× Inter Miami CF | | Inter Miami CF |
| 31 de ago.21:30 | Austin FC× Vancouver Whitecaps | | Vancouver Whitecaps |
| 31 de ago.22:30 | Real Salt Lake× New England Revolution | | New England Revolution |
| 31 de ago.23:30 | San Jose Earthquakes× Minnesota United | | Minnesota United |
| 31 de ago.23:30 | Portland Timbers× Seattle Sounders FC | | Seattle Sounders FC |
| 31 de ago.23:30 | Los Angeles FC× Houston Dynamo | | Houston Dynamo |
| 01 de set.15:45 | St.Louis City× LA Galaxy | | LA Galaxy |
| 07 de set.20:30 | New York Red Bulls× Sporting Kansas City | | Sporting Kansas City |
| 07 de set.20:30 | Columbus Crew× Seattle Sounders FC | | Seattle Sounders FC |
| 07 de set.20:30 | New England Revolution× St.Louis City | | St.Louis City |
| 07 de set.21:30 | Chicago Fire× DC United | | DC United |
| 07 de set.21:30 | Houston Dynamo× Los Angeles FC | | Los Angeles FC |
| 07 de set.23:30 | Vancouver Whitecaps× FC Dallas | | FC Dallas |
| 14 de set.20:30 | CF Montréal× Charlotte FC | | Charlotte FC |
| 14 de set.20:30 | Toronto FC× Austin FC | | Austin FC |
| 14 de set.20:30 | DC United× New York City FC | | New York City FC |
| 14 de set.20:30 | Orlando City SC× New England Revolution | | New England Revolution |
| 14 de set.20:30 | FC Cincinnati× Columbus Crew | | Columbus Crew |
| 14 de set.20:30 | Inter Miami CF× Philadelphia Union | | Philadelphia Union |
| 14 de set.20:30 | Atlanta United× Nashville SC | | Nashville SC |
| 14 de set.21:30 | St.Louis City× Minnesota United | | Minnesota United |
| 14 de set.21:30 | Houston Dynamo× Real Salt Lake | | Real Salt Lake |
| 14 de set.21:30 | Chicago Fire× New York Red Bulls | | New York Red Bulls |
| 14 de set.22:30 | Colorado Rapids× Portland Timbers | | Portland Timbers |
| 14 de set.23:30 | Vancouver Whitecaps× San Jose Earthquakes | | San Jose Earthquakes |
| 14 de set.23:30 | LA Galaxy× Los Angeles FC | | Los Angeles FC |
| 15 de set.20:15 | Seattle Sounders FC× Sporting Kansas City | | Sporting Kansas City |
| 18 de set.20:30 | New York City FC× Philadelphia Union | | Philadelphia Union |
| 18 de set.20:30 | Atlanta United× Inter Miami CF | | Inter Miami CF |
| 18 de set.20:30 | New England Revolution× CF Montréal | | CF Montréal |
| 18 de set.20:30 | Toronto FC× Columbus Crew | | Columbus Crew |
| 18 de set.21:15 | Orlando City SC× Charlotte FC | | Charlotte FC |
| 18 de set.21:30 | Sporting Kansas City× Colorado Rapids | | Colorado Rapids |
| 18 de set.21:30 | Houston Dynamo× Vancouver Whitecaps | | Vancouver Whitecaps |
| 18 de set.21:30 | Nashville SC× Chicago Fire | | Chicago Fire |
| 18 de set.21:30 | Minnesota United× FC Cincinnati | | FC Cincinnati |
| 18 de set.22:30 | Real Salt Lake× FC Dallas | | FC Dallas |
| 18 de set.23:30 | Seattle Sounders FC× San Jose Earthquakes | | San Jose Earthquakes |
| 18 de set.23:30 | Portland Timbers× LA Galaxy | | LA Galaxy |
| 18 de set.23:30 | Los Angeles FC× Austin FC | | Austin FC |
| 21 de set.15:00 | New York City FC× Inter Miami CF | | Inter Miami CF |
| 21 de set.17:00 | Charlotte FC× New England Revolution | | New England Revolution |
| 21 de set.20:30 | New York Red Bulls× Atlanta United | | Atlanta United |
| 21 de set.20:30 | Columbus Crew× Orlando City SC | | Orlando City SC |
| 21 de set.20:30 | CF Montréal× Chicago Fire | | Chicago Fire |
| 21 de set.21:30 | Austin FC× Houston Dynamo | | Houston Dynamo |
| 21 de set.21:30 | Sporting Kansas City× Minnesota United | | Minnesota United |
| 21 de set.21:30 | Nashville SC× FC Cincinnati | | FC Cincinnati |
| 21 de set.21:30 | FC Dallas× Los Angeles FC | | Los Angeles FC |
| 21 de set.22:30 | Real Salt Lake× Portland Timbers | | Portland Timbers |
| 21 de set.22:30 | Colorado Rapids× Toronto FC | | Toronto FC |
| 21 de set.23:30 | LA Galaxy× Vancouver Whitecaps | | Vancouver Whitecaps |
| 21 de set.23:30 | San Jose Earthquakes× St.Louis City | | St.Louis City |
| 22 de set.19:15 | Philadelphia Union× DC United | | DC United |
| 28 de set.20:30 | CF Montréal× San Jose Earthquakes | | San Jose Earthquakes |
| 28 de set.20:30 | New England Revolution× Nashville SC | | Nashville SC |
| 28 de set.20:30 | DC United× Columbus Crew | | Columbus Crew |
| 28 de set.20:30 | New York Red Bulls× New York City FC | | New York City FC |
| 28 de set.20:30 | FC Cincinnati× Los Angeles FC | | Los Angeles FC |
| 28 de set.20:30 | Inter Miami CF× Charlotte FC | | Charlotte FC |
| 28 de set.20:30 | Philadelphia Union× Atlanta United | | Atlanta United |
| 28 de set.21:30 | Chicago Fire× Toronto FC | | Toronto FC |
| 28 de set.21:30 | St.Louis City× Sporting Kansas City | | Sporting Kansas City |
| 28 de set.21:30 | Minnesota United× Colorado Rapids | | Colorado Rapids |
| 28 de set.21:30 | FC Dallas× Orlando City SC | | Orlando City SC |
| 28 de set.21:30 | Austin FC× Real Salt Lake | | Real Salt Lake |
| 28 de set.23:30 | Seattle Sounders FC× Houston Dynamo | | Houston Dynamo |
| 28 de set.23:30 | Vancouver Whitecaps× Portland Timbers | | Portland Timbers |
| 02 de out.20:30 | Atlanta United× CF Montréal | | CF Montréal |
| 02 de out.20:30 | Toronto FC× New York Red Bulls | | New York Red Bulls |
| 02 de out.20:30 | Charlotte FC× Chicago Fire | | Chicago Fire |
| 02 de out.20:30 | New York City FC× FC Cincinnati | | FC Cincinnati |
| 02 de out.20:30 | Orlando City SC× Philadelphia Union | | Philadelphia Union |
| 02 de out.20:45 | Columbus Crew× Inter Miami CF | | Inter Miami CF |
| 02 de out.21:30 | Nashville SC× DC United | | DC United |
| 02 de out.21:30 | Houston Dynamo× New England Revolution | | New England Revolution |
| 02 de out.22:30 | Real Salt Lake× Minnesota United | | Minnesota United |
| 02 de out.22:30 | Colorado Rapids× LA Galaxy | | LA Galaxy |
| 02 de out.23:30 | San Jose Earthquakes× FC Dallas | | FC Dallas |
| 02 de out.23:30 | Portland Timbers× Austin FC | | Austin FC |
| 02 de out.23:30 | Los Angeles FC× St.Louis City | | St.Louis City |
| 02 de out.23:30 | Vancouver Whitecaps× Seattle Sounders FC | | Seattle Sounders FC |
| 05 de out.17:00 | Toronto FC× Inter Miami CF | | Inter Miami CF |
| 05 de out.20:30 | Vancouver Whitecaps× Minnesota United | | Minnesota United |
| 05 de out.20:30 | Charlotte FC× CF Montréal | | CF Montréal |
| 05 de out.20:30 | New England Revolution× DC United | | DC United |
| 05 de out.20:30 | Atlanta United× New York Red Bulls | | New York Red Bulls |
| 05 de out.20:30 | Columbus Crew× Philadelphia Union | | Philadelphia Union |
| 05 de out.20:30 | FC Cincinnati× Orlando City SC | | Orlando City SC |
| 05 de out.21:30 | St.Louis City× Houston Dynamo | | Houston Dynamo |
| 05 de out.21:30 | Sporting Kansas City× Los Angeles FC | | Los Angeles FC |
| 05 de out.22:30 | Colorado Rapids× Seattle Sounders FC | | Seattle Sounders FC |
| 05 de out.23:30 | LA Galaxy× Austin FC | | Austin FC |
| 05 de out.23:30 | San Jose Earthquakes× Real Salt Lake | | Real Salt Lake |
| 06 de out.17:25 | New York City FC× Nashville SC | | Nashville SC |
| 06 de out.20:00 | Portland Timbers× FC Dallas | | FC Dallas |
| 12 de out.20:30 | Columbus Crew× New England Revolution | | New England Revolution |
| 13 de out.20:30 | Vancouver Whitecaps× Los Angeles FC | | Los Angeles FC |
| 19 de out.19:00 | DC United× Charlotte FC | | Charlotte FC |
| 19 de out.19:00 | Chicago Fire× Nashville SC | | Nashville SC |
| 19 de out.19:00 | CF Montréal× New York City FC | | New York City FC |
| 19 de out.19:00 | Orlando City SC× Atlanta United | | Atlanta United |
| 19 de out.19:00 | Philadelphia Union× FC Cincinnati | | FC Cincinnati |
| 19 de out.19:00 | Inter Miami CF× New England Revolution | | New England Revolution |
| 19 de out.19:00 | New York Red Bulls× Columbus Crew | | Columbus Crew |
| 19 de out.22:00 | Los Angeles FC× San Jose Earthquakes | | San Jose Earthquakes |
| 19 de out.22:00 | Minnesota United× St.Louis City | | St.Louis City |
| 19 de out.22:00 | Real Salt Lake× Vancouver Whitecaps | | Vancouver Whitecaps |
| 19 de out.22:00 | FC Dallas× Sporting Kansas City | | Sporting Kansas City |
| 19 de out.22:00 | Seattle Sounders FC× Portland Timbers | | Portland Timbers |
| 19 de out.22:00 | Houston Dynamo× LA Galaxy | | LA Galaxy |
| 19 de out.22:00 | Austin FC× Colorado Rapids | | Colorado Rapids |
| 22 de out.20:30 | CF Montréal× Atlanta United | pên. 4–5 | Atlanta United |
| 23 de out.23:30 | Vancouver Whitecaps× Portland Timbers | | Portland Timbers |
| 25 de out.21:30 | Inter Miami CF× Atlanta United | | Atlanta United |
| 27 de out.00:00 | LA Galaxy× Colorado Rapids | | Colorado Rapids |
| 27 de out.20:30 | Orlando City SC× Charlotte FC | | Charlotte FC |
| 27 de out.22:45 | Los Angeles FC× Vancouver Whitecaps | | Vancouver Whitecaps |
| 28 de out.19:55 | FC Cincinnati× New York City FC | | New York City FC |
| 28 de out.21:50 | Seattle Sounders FC× Houston Dynamo | pên. 5–4 | Houston Dynamo |
| 29 de out.19:45 | Columbus Crew× New York Red Bulls | | New York Red Bulls |
| 29 de out.22:00 | Real Salt Lake× Minnesota United | pên. 4–5 | Minnesota United |
| 01 de nov.20:30 | Charlotte FC× Orlando City SC | pên. 3–1 | Orlando City SC |
| 01 de nov.22:30 | Colorado Rapids× LA Galaxy | | LA Galaxy |
| 02 de nov.18:00 | New York City FC× FC Cincinnati | | FC Cincinnati |
| 02 de nov.20:00 | Atlanta United× Inter Miami CF | | Inter Miami CF |
| 02 de nov.22:00 | Minnesota United× Real Salt Lake | pên. 3–1 | Real Salt Lake |
| 03 de nov.18:30 | New York Red Bulls× Columbus Crew | pên. 5–4 | Columbus Crew |
| 03 de nov.20:30 | Houston Dynamo× Seattle Sounders FC | pên. 6–7 | Seattle Sounders FC |
| 03 de nov.22:45 | Vancouver Whitecaps× Los Angeles FC | | Los Angeles FC |
| 09 de nov.00:30 | Los Angeles FC× Vancouver Whitecaps | | Vancouver Whitecaps |
| 09 de nov.18:00 | FC Cincinnati× New York City FC | pên. 5–6 | New York City FC |
| 09 de nov.20:00 | Orlando City SC× Charlotte FC | pên. 4–1 | Charlotte FC |
| 09 de nov.22:00 | Inter Miami CF× Atlanta United | | Atlanta United |
| 30 de nov.21:30 | Orlando City SC× New York Red Bulls | | New York Red Bulls |
| 01 de dez.00:00 | LA Galaxy× Seattle Sounders FC | | Seattle Sounders FC |
| 07 de dez.18:00 | LA Galaxy× New York Red Bulls | | New York Red Bulls |
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